Nose to Brain Transport

The blood-brain barrier that separates the brain interstitial fluid from the circulating blood provides an efficient barrier for the diffusion of most drugs from the blood to receptors in the central nervous system (CNS). This limits drug treatment of CNS diseases, such as Parkinson's and Alzheimer's diseases. In recent years, interest has been expressed in the use of the nasal route to deliver drugs to the brain, exploiting the olfactory pathway. Read about the clinical success of ViaNase in nasally delivering insulin in Alzheimer's patients.

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